10 March 2025
mRNA localization is key for cell migration. Boraas et al identify hundreds of FA-enriched mRNAs & reveal that G3BP1 RNPs regulate FA function. By enhancing FA protein mobility & size, G3BP1 promotes cell speed—unveiling a new role beyond stress response.
25 February 2025
HIV-1 gene expression is tightly regulated at multiple levels. Using RiboLace & proteomics, Labaronne et al reveal how translation & post-translational mechanisms shape infection. Notably, how uORF-derived peptides elicit immune responses.
19 February 2025
Ovarian endometriosis impacts oocyte quality, but the molecular mechanisms remain unclear. Using RiboLace pulldown, Diao et al reveal key translatomic and transcriptomic pathways—oxidative stress, meiosis, and spliceosome—linked to infertility
20 January 2025
Antifungal resistance in Aspergillus fumigatus is rising. Using nano-tRNAseq, Bruch et al show that Mod5 deletion alters stress responses and unexpectedly confers 5-FC resistance via CPC pathway activation and nmeA upregulation.
6 January 2025
Rhabdoid tumors, driven by SMARCB1 loss, show sensitivity to the translation inhibitor homoharringtonine. Using RiboLace, Nguyen et al reveal SMARCB1’s role in translation, impacting global translation and mRNA efficiency, particularly in differentiation
18 July 2024
Translation regulates gene expression and function. The study explores tRNA expression and translation in bovine tissues, having identified tissue-specific gene modulation and pausing sites. These were shown to influence translation and protein folding.
