Non-AUG start codons are used more than expected, leading to diverse protein forms with potentially new functions. New methods reveal these "alternative translation initiation sites" (aTIS).
Maria Luisa Malosio, Research Scientist at the National Research Council (CNR) in Milan, Italy, talks about translation and its role in her research with metabolic condition (like Type-2 Diabetes) and cognitive decline (e.g. Alzheimer)
It was a pleasure talking to Paola Falletta, Senior Postdoc at the Cancer Imaging Unit at I.R.C.C.S. Ospedale San Raffaele, Milan, Italy, about her research on triple negative breast cancer and translation analysis
Emiliano Ricci, Group Leader at the Department of Biology and Modeling of the Cell at the École Normale Supérieure de Lyon In France, talks about translation and its role in his research on virus replication,
Current methods miss details of active protein production. RiboLace isolates active ribosomes without tags, offering better data quality with less sample. It even captures disomes, potentially revealing new aspects of translation and disease links.
Cancerous HRAS gene has more m6A marks, boosting protein and promoting cancer. Specific sites and interacting proteins identified, offering a new target for therapy. This link between m6A and cancer progression holds promise for future treatments.
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